Chrm5^tm1Yeo
Targeted Allele Detail

Summary

• Symbol: Chrm5^tm1Yeo
• Name: cholinergic receptor, muscarinic 5; targeted mutation 1, John Yeomans
• MGI ID: MGI:2661114
• Synonyms: M5 KO
• Gene: Chrm5 Location: Chr2:112309516-112311114 bp, - strand Genetic Position: Chr2, 57.02 cM
• Alliance: Chrm5^tm1Yeo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83217
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The endogenous gene was disrupted by a neomycin selection cassette inserted by homologous recombination. The deleted region encoded a portion of the third intracellular loop. (J:83217)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrm5 Mutation: 40 strains or lines available

References

• Original: J:83217 Takeuchi J, et al., Increased drinking in mutant mice with truncated M5 muscarinic receptor genes. Pharmacol Biochem Behav. 2002 May;72(1-2):117-23
• All: 4 reference(s)