Rtn4^tm1Matl
Targeted Allele Detail

Summary

• Symbol: Rtn4^tm1Matl
• Name: reticulon 4; targeted mutation 1, Marc Tessier-Lavigne
• MGI ID: MGI:2661136
• Synonyms: Nogo^-, Nogo-A/B, nogo-ab^atg
• Gene: Rtn4 Location: Chr11:29642947-29694331 bp, + strand Genetic Position: Chr11, 16.79 cM
• Alliance: Rtn4^tm1Matl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83192
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Modified isoform(s), Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region of exon 1, which is specific to isoforms A and B (but not to isoform C), was replaced with a cassette containing IRES-GFPLacZ-loxP and an frt flanked hprt. Northern blot analysis of homozygous mutant brain tissue indicated an absence of A and B transcript and confirmed the presence of C transcript. The A and B isoforms were undetected by Western blot analysis. (J:83192)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rtn4 Mutation: 131 strains or lines available

References

• Original: J:83192 Zheng B, et al., Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron. 2003 Apr 24;38(2):213-24
• All: 12 reference(s)