Lmr14^CcS16/Dem
QTL Variant Detail

Summary

• QTL variant: Lmr14^CcS16/Dem
• Name: leishmaniasis resistance 14; CcS16/Dem
• MGI ID: MGI:2661196
• QTL: Lmr14 Location: Chr2:103095716-103095823 bp Genetic Position: Chr2, cM position of peak correlated region/allele: 62.98 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: CcS16/Dem

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele is associated with increased splenomegaly, hepatomegaly, increased serum IFN-gamma, and increased serum IL-12 compared to BALB/cHeA. (J:82716, J:108764)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Notes

Interaction between Lmr5 BALB/cHeA alleles and STS/A or BALB/cHeA homozygosity at Lmr14 increases IgE levels.

Lmr14 exhibits additive inheritance.

Lmr5 interacts with Lmr14 on chromosome 2. Animals homozygous for STS/A-derived alleles at both Lmr5 and Lmr14 exhibit the highest levels of serum IL-12.

Homozygosity for STS/A alleles at Lmr13 and Lmr14 confers decreased serum TNF-alpha. Each locus alone has minimal effect.

References

• Original: J:82717 Badalova J, et al., Separation and mapping of multiple genes that control IgE level in Leishmania major infected mice. Genes Immun. 2002 Jun;3(4):187-95
• All: 3 reference(s)