Rtn4^tm3Matl
Targeted Allele Detail

Summary

• Symbol: Rtn4^tm3Matl
• Name: reticulon 4; targeted mutation 3, Marc Tessier-Lavigne
• MGI ID: MGI:2661203
• Synonyms: Nogo N/C double
• Gene: Rtn4 Location: Chr11:29642947-29694331 bp, + strand Genetic Position: Chr11, 16.79 cM
• Alliance: Rtn4^tm3Matl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83192
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph, Reporter)
• Mutation: Insertion
• Mutation details: The amino and carboxy terminals were targeted in cis to generate an allele from which no protein is produced. The amino terminal was disrupted by the insertion of IRES-GFPLacZ-loxP and an frt-flanked hprt cassette. A floxed neo cassette disrupted the carboxy terminal exon encoding the first transmembrane domain, common to all isoforms. (J:83192, J:151085)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rtn4 Mutation: 131 strains or lines available

References

• Original: J:83192 Zheng B, et al., Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron. 2003 Apr 24;38(2):213-24
• All: 4 reference(s)