Rtn4^tm3.1Matl
Targeted Allele Detail

Summary

• Symbol: Rtn4^tm3.1Matl
• Name: reticulon 4; targeted mutation 3.1, Marc Tessier-Lavigne
• MGI ID: MGI:2661204
• Gene: Rtn4 Location: Chr11:29642947-29694331 bp, + strand Genetic Position: Chr11, 16.79 cM
• Alliance: Rtn4^tm3.1Matl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83192
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The genomic fragment flanked by a single loxP site in intron 1 and a floxed neo cassette that had replaced exon 5 was excised from Rtn4^tm3Matl via cre mediated recombination in the germline. The IRES-GFPLacZ cassette remained in exon 1. RT-PCR confirmed gene inactivation for all three isoforms. (J:83192, J:151085)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rtn4 Mutation: 131 strains or lines available

References

• Original: J:83192 Zheng B, et al., Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron. 2003 Apr 24;38(2):213-24
• All: 3 reference(s)