Scon2^129P3/J
QTL Variant Detail

Summary

• QTL variant: Scon2^129P3/J
• Name: sucrose consumption 2; 129P3/J
• MGI ID: MGI:2661435
• Synonyms: Scon2^129/J
• QTL: Scon2 Location: Chr4:151654451-151654550 bp Genetic Position: Chr4, cM position of peak correlated region/allele: 82.64 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: 129P3/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased sucrose consumption compared to C57BL/6J.
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:42179

Interval mapping was performed on 171 male mice from a (C57BL/6ByJ x 129/J)F2 cross to identify QTLs associated with sucrose consumption. Parental strain C57BL/6ByJ consumes more sucrose compared to parental strain 129/J. Two QTLs, Scon1 and Scon2, were identified on mouse Chromosome 4. Scon1 maps from 8.55 cM - 21.55 cM with a peak LOD score of 3.47 at D4Mit4 (12.1 cM). C57BL/6ByJ-derived alleles confer increased sucrose consumption with incomplete recessive inheritance at Scon1. Scon2 maps from 78 cM -88 cM with a peak LOD score of 5.82 at D4Mit42 (81 cM). C57BL/6ByJ-derived alleles confer increased sucrose consumption with a dominant mode of inheritance at Scon2. Together, Scon1 and Scon2 explain approximately 41% of the phenotypic variance. A possible candidate gene for Scon2 is Gnb1.

References

• Original: J:42179 Bachmanov AA, et al., Sucrose consumption in mice: major influence of two genetic loci affecting peripheral sensory responses. Mamm Genome. 1997 Aug;8(8):545-8
• All: 2 reference(s)