Tal1^tm2Sho
Targeted Allele Detail

Summary

• Symbol: Tal1^tm2Sho
• Name: T cell acute lymphocytic leukemia 1; targeted mutation 2, Stuart Orkin
• MGI ID: MGI:2661471
• Synonyms: SCL^fl
• Gene: Tal1 Location: Chr4:114913623-114928952 bp, + strand Genetic Position: Chr4, 52.73 cM
• Alliance: Tal1^tm2Sho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83215
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into the intron preceding the bHLH region and a floxed neomycin cassette was inserted into the 3' untranslated region via homologous recombination. (J:83215)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tal1 Mutation: 33 strains or lines available

References

• Original: J:83215 Mikkola HK, et al., Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature. 2003 Jan 30;421(6922):547-51
• All: 8 reference(s)