Hfib1^BALB/cJ
QTL Variant Detail

Summary

• QTL variant: Hfib1^BALB/cJ
• Name: hepatic fibrogenesis 1; BALB/cJ
• MGI ID: MGI:2661489
• QTL: Hfib1 Location: Chr15:64306334-64306479 bp Genetic Position: Chr15, cM position of peak correlated region/allele: 29.03 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: BALB/cJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to hepatic fibrosis compared to A/J. (J:80619)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:80619

Linkage analysis was performed on 358 animals from an (A/J x BALB/cJ)F2 cross with an average marker resolution of 20 cM to identify QTLs influencing hepatic fibrosis. Parental strain BALB/cJ is susceptible to hepatic fibrosis whereas parental strain A/Jis resistant. A significant locus at 21.5 cM on mouse Chromosome 15 was identified and named Hfib1. Hfib1 gives a peak LOD score of 4.0 at D15Mit122. BALB/cJ-derived alleles confer recessively inherited susceptibility to hepatic fibrosis at Hfib1.

References

• Original: J:80619 Hillebrandt S, et al., Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfib1 on chromosome 15. Gastroenterology. 2002 Dec;123(6):2041-51
• All: 1 reference(s)