Cfld3^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Cfld3^C57BL/6J
• Name: cystic fibrosis lung disease 3; C57BL/6J
• MGI ID: MGI:2661743
• QTL: Cfld3 Location: Chr17:10081340-10081639 bp Genetic Position: Chr17, cM position of peak correlated region/allele: 7.65 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased lung fibrosis in male animals compared to BALB/cJ. (J:80598)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Cfld2 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:80598

216 (C57BL/6J-Cftr^tm1Unc x BALB/cJ-Cftr^tm1Unc)F2 animals were typed for 114 microsatellite markers at an average spacing of 15 cM to identify QTLs affecting cystic fibrosis-associated lung disease. Parental strain C57BL/6J-Cftr^tm1Unc exhibits increased collagen deposition and alveolar interstitial thickening compared to BALB/cJ-Cftr^tm1Unc. A QTL named Cfld1 (cystic fibrosis lung disease 1) mapped from 83 cM - 107 cM on mouse Chromosome 2 with a LOD score of 3.0 at D2Mit528 (87.4 cM). Cfld1 is associated with lung fibrosis with BALB/cJ-derived alleles exhibiting recessive inheritance. Cfld2 mapped from 61.5 cM - 74.1 cM on mouse Chromosome 6 with a LOD score of 3.4 at D6Mit198 (67 cM). BALB/cJ-derived alleles confer additively inherited lung fibrosis at Cfld2. Cfld3 mapped from 4.1 cM - 16.4 cM on mouse Chromosome 17 with a LOD score of 3.2 at D17Mit57 (7.6 cM). Cfld3 is associated with lung fibrosis in male animals with C57BL/6J-derived alleles exhibiting additive inheritance. Cfld4 mapped to 50.3 cM - 60 cM on mouse Chromosome 7 with a LOD score of 3.1 at D7Mit238 (53 cM). Cfld4 is associated with alveoli count in female animals with BALB/cJ-derived alleles exhibiting dominant inheritance.

References

• Original: J:80598 Haston CK, et al., Detection of modifier loci influencing the lung phenotype of cystic fibrosis knockout mice. Mamm Genome. 2002 Nov;13(11):605-13
• All: 1 reference(s)