Mprf^SM/J
QTL Variant Detail

Summary

• QTL variant: Mprf^SM/J
• Name: maternal performance; SM/J
• MGI ID: MGI:2661775
• QTL: Mprf Location: unknown Genetic Position: Chr7, cM position of peak correlated region/allele: 1.91 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: Heterozygous females exhibit decreased maternal performance compared to LG/J or SM/J homozygous females. (J:80533)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:80533

214 (LG/J x SM/J)F2 female animals were genotyped for 96 microsatellite markers to identify QTLs associated with maternal performance. Successful maternal performance was measured by survival of the litter 1 week after birth. Parental strain LG/J exhibits lower rates of maternal success compared to parental strain SM/J. A QTL showing significance at the genome-wide level, Mprf (maternal performance), mapped to 0.5 cM on mouse Chromosome 7 with a LOD score of 3.21 at D7Mit21. This locus shows underdominance where heterozygous females are less successful than homozygous females of either genotype. A suggestive locus mapped to 69 cM on mouse Chromosome 2 with a LOD score of 2.43 at D2Mit17. The chromosome 2 locus exhibits overdominance where heterozygous females exhibit greater maternal success compared to homozygous females. 15 epistatic interactions involving 23 loci were also mapped to all chromosomes except 12, 16, and 17.

References

• Original: J:80533 Peripato AC, et al., Quantitative trait Loci for maternal performance for offspring survival in mice. Genetics. 2002 Nov;162(3):1341-53
• All: 1 reference(s)