Nociq2^A/J
QTL Variant Detail

Summary

• QTL variant: Nociq2^A/J
• Name: nociceptive sensitivity inflammatory QTL 2; A/J
• MGI ID: MGI:2661861
• QTL: Nociq2 Location: Chr10:122041304-122041528 bp Genetic Position: Chr10, cM position of peak correlated region/allele: 70.36 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: A/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased sensitivity to formalin-induced nociception. (J:79707)
• Inheritance: Other (see notes)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:79707

203 (C57BL/6J x A/J)F2 mice were screened for 90 microsatellite markers at an average spacing of 22 cM to identify QTLs associated with formalin-induced nociception. Parental strain C57BL/6J is more sensitive to formalin-induced nociception compared to parental strain A/J. Two significant QTLs, Nociq1 and Nociq2, mapped to 55 cM on mouse Chromosome 9 and to 69 cM on mouse Chromosome 10, respectively. Nociq1 has a QTL range of 44 cM - 68 cM and gives a peak LOD score of 5.2 at D9Mit182. C57BL/6J-derived alleles confer increased hindlimb licking 0-10 minutes after formalin injection (early/acute phase) with dominant inheritance. Nociq2 has a QTL range of 34 cM - tel and gives a peak LOD score of 4.3 at D10Mit35a. C57BL/6J-derived alleles confer increased hindlimb licking 0-10 minutes (early/acute phase) and 10-90 minutes (late phase) after formalin injection. Nociq2 exhibits either dominant or additive inheritance.

References

• Original: J:79707 Wilson SG, et al., Identification of quantitative trait loci for chemical/inflammatory nociception in mice. Pain. 2002 Apr;96(3):385-91
• All: 1 reference(s)