Fat1^tm1Cfc
Targeted Allele Detail

Summary

• Symbol: Fat1^tm1Cfc
• Name: FAT atypical cadherin 1; targeted mutation 1, Charles ffrench-Constant
• MGI ID: MGI:2662293
• Synonyms: mFAT1^-
• Gene: Fat1 Location: Chr8:45388484-45505294 bp, + strand Genetic Position: Chr8, 24.81 cM
• Alliance: Fat1^tm1Cfc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83058
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of an in-frame lacZ-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of skin proteins. (J:83058)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fat1 Mutation: 208 strains or lines available

References

• Original: J:83058 Ciani L, et al., Mice Lacking the Giant Protocadherin mFAT1 Exhibit Renal Slit Junction Abnormalities and a Partially Penetrant Cyclopia and Anophthalmia Phenotype. Mol Cell Biol. 2003 May;23(10):3575-82
• All: 5 reference(s)