Ppp1r3c^tm1Ars
Targeted Allele Detail

Summary

• Symbol: Ppp1r3c^tm1Ars
• Name: protein phosphatase 1, regulatory subunit 3C; targeted mutation 1, Alan R Saltiel
• MGI ID: MGI:2662307
• Synonyms: PTG^-
• Gene: Ppp1r3c Location: Chr19:36709131-36714004 bp, - strand Genetic Position: Chr19, 31.89 cM, cytoband C3
• Alliance: Ppp1r3c^tm1Ars page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83297
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: The entire coding region was replaced with a neo cassette inserted by homologous recombination. Western blot analysis of adipose, liver, and muscle tissue showed reduced levels of protein in homozygous mutant mice. (J:83297)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp1r3c Mutation: 19 strains or lines available

References

• Original: J:83297 Crosson SM, et al., PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance. J Clin Invest. 2003 May;111(9):1423-32
• All: 3 reference(s)