Slit3^tm1.1Dor
Targeted Allele Detail

Summary

• Symbol: Slit3^tm1.1Dor
• Name: slit guidance ligand 3; targeted mutation 1.1, David M Ornitz
• MGI ID: MGI:2662358
• Gene: Slit3 Location: Chr11:35012283-35599334 bp, + strand Genetic Position: Chr11, 20.29 cM, cytoband A5
• Alliance: Slit3^tm1.1Dor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83292
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The floxed neo cassette was excised from Slit3^tm1Dor via cre-mediated recombination. The Beta-gal gene was left in place of the the 3' portion of exon 1 (194 nt) and approximately 800 nt of intron 1. (J:83292)

Disease models

Expression

In Mice Carrying this Mutation:	27 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slit3 Mutation: 81 strains or lines available

References

• Original: J:83292 Yuan W, et al., A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5217-22
• All: 27 reference(s)