Gmcl1^{Gt(OST6847)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Gmcl1^{Gt(OST6847)Lex}
• Name: germ cell-less, spermatogenesis associated 1; gene trap OST6847, Lexicon Genetics
• MGI ID: MGI:2662409
• Synonyms: Gmcl1^{Gt(Betageo)470Lex}, Gmcl1^{Gt(VICT20)1Nkn}, mgcl-1^OST6847
• Gene: Gmcl1 Location: Chr6:86668750-86710365 bp, - strand Genetic Position: Chr6, 37.75 cM
• Alliance: Gmcl1^{Gt(OST6847)Lex} page

Mutation origin

• Mutant Cell Line: OST6847
• Germline Transmission: Earliest citation of germline transmission: J:81819
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene was disrupted by insertion of a retroviral vector (VICTR20) into the coding region. Neither the full length nor truncated protein product was detected in homozygous mutant mice as assayed by Western blot analysis of testes extracts. (J:81819)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST6847	CG477087 ; (MGI Seq Detail)	3' RACE	Chr6:86669670-86670026 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  2 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gmcl1 Mutation: 40 strains or lines available

References

• Original: J:81819 Kimura T, et al., Mouse germ cell-less as an essential component for nuclear integrity. Mol Cell Biol. 2003 Feb;23(4):1304-15
• All: 2 reference(s)