Sh2b1^tm1Ayos
Targeted Allele Detail

Summary

• Symbol: Sh2b1^tm1Ayos
• Name: SH2B adaptor protein 1; targeted mutation 1, Akihiko Yoshimura
• MGI ID: MGI:2662436
• Synonyms: Sh2B^-
• Gene: Sh2b1 Location: Chr7:126066166-126074596 bp, - strand Genetic Position: Chr7, 69.06 cM
• Alliance: Sh2b1^tm1Ayos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78931
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A genomic fragment extending from within exon 2 through exon 8 was replaced with a PGK-neo cassette inserted by homologous recombination. The deleted region encoded the PH and SH2 domains of the protein. Transcript was undetected in the cerebellums of homozygous mutant mice by Northern blot analysis. (J:78931)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sh2b1 Mutation: 49 strains or lines available

References

• Original: J:78931 Ohtsuka S, et al., SH2-B is required for both male and female reproduction. Mol Cell Biol. 2002 May;22(9):3066-77
• All: 4 reference(s)