Ica1^tm1Mdos
Targeted Allele Detail

Summary

• Symbol: Ica1^tm1Mdos
• Name: islet cell autoantigen 1; targeted mutation 1, H Michael Dosch
• MGI ID: MGI:2662437
• Synonyms: ICA69^null
• Gene: Ica1 Location: Chr6:8630527-8778488 bp, - strand Genetic Position: Chr6, 4.38 cM, cytoband A1-A2
• Alliance: Ica1^tm1Mdos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83526
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a tTA-neo cassette into the Tep69 epitope sequence of exon 2 via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of brain and salivary gland proteins. (J:83526)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ica1 Mutation: 41 strains or lines available

References

• Original: J:83526 Winer S, et al., ICA69(null) nonobese diabetic mice develop diabetes, but resist disease acceleration by cyclophosphamide. J Immunol. 2002 Jan 1;168(1):475-82
• All: 7 reference(s)