Ahl2^NOD/ShiLtJ
QTL Variant Detail

Summary

• QTL variant: Ahl2^NOD/ShiLtJ
• Name: age related hearing loss 2; NOD/ShiLtJ
• MGI ID: MGI:2662446
• QTL: Ahl2 Location: Chr5:79650568-79650688 bp Genetic Position: Chr5, cM position of peak correlated region/allele: 42.22 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NOD/ShiLtJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers hearing loss compared to C57BL/6J. (J:81197)
• Inheritance: Recessive

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:81197

110 (NOD/LtJ x C57BL/6J)F1 x NOD/LtJ backcross animals were typed for 90 microsatellite markers to identify loci linked to age-related hearing loss. Parental strain NOD/LtJ exhibits profound hearing loss at 6 months of age as measured by auditory brainstem response (ABR) threshold. A QTL mapped to 44 cM on mouse Chromosome 5 with a LOD score of 5.5 at D5Mit309. NOD/LtJ-derived alleles confer recessively inherited hearing loss at this locus, named Ahl2.

The authors also analyzed a (CAST/Ei x NOD/LtJ)F1 x NOD/LtJ backcross population and mapped a significant QTL with LOD=4 to 42 cM at D5Mit235. This most likely represents the same locus, Ahl2. Again, NOD/LtJ-derived alleles confer recessively inherited hearing loss at this locus.

10.13.2015 Curators Note: Because Ahl2 was originally mapped here using the (NOD/LtJ x C57BL/6J)F1 x NOD/LtJ backcross, which differs from the second cross, we consider the second cross a separate mapping experiment and have named that QTL Ahl7.

References

• Original: J:81197 Johnson KR, et al., Ahl2, a second locus affecting age-related hearing loss in mice. Genomics. 2002 Nov;80(5):461-4
• All: 1 reference(s)