Elf3^tm1Pjh
Targeted Allele Detail

Summary

• Symbol: Elf3^tm1Pjh
• Name: E74-like factor 3; targeted mutation 1, Paul J Hertzog
• MGI ID: MGI:2662485
• Synonyms: Elf3^-
• Gene: Elf3 Location: Chr1:135181312-135186210 bp, - strand Genetic Position: Chr1, 58.42 cM, cytoband F
• Alliance: Elf3^tm1Pjh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76344
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted by the insertion of a cassette containing lacZ and neo. An elongated transcript resulting from readthrough of the polyadenylation signal of the selection cassette was detected by Northern blot analysis of mutant mice. While protein analysis was not conducted, the allele was putatively null due to stop codons within the neo gene. (J:76344)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Elf3 Mutation: 39 strains or lines available

References

• Original: J:76344 Ng AY, et al., Inactivation of the transcription factor Elf3 in mice results in dysmorphogenesis and altered differentiation of intestinal epithelium. Gastroenterology. 2002 May;122(5):1455-66
• All: 5 reference(s)