Thpo^tm1Mwm
Targeted Allele Detail

Summary

• Symbol: Thpo^tm1Mwm
• Name: thrombopoietin; targeted mutation 1, Mark W Moore
• MGI ID: MGI:2662551
• Synonyms: TPO-
• Gene: Thpo Location: Chr16:20543204-20553261 bp, - strand Genetic Position: Chr16, 12.51 cM
• Alliance: Thpo^tm1Mwm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83262
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct introduces a neo cassette into the 4th exon of the gene, replacing sequences encoding 23 amino acids in the domain responsible for receptor binding and activation. mRNA was not detected in the liver and kidney of mutant animals. (J:83262)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thpo Mutation: 23 strains or lines available

References

• Original: J:83262 de Sauvage FJ, et al., Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J Exp Med. 1996 Feb 1;183(2):651-6
• All: 20 reference(s)