Xrcc2^tm1Jtk
Targeted Allele Detail

Summary

• Symbol: Xrcc2^tm1Jtk
• Name: X-ray repair complementing defective repair in Chinese hamster cells 2; targeted mutation 1, John Thacker
• MGI ID: MGI:2662686
• Synonyms: Xrcc2^-
• Gene: Xrcc2 Location: Chr5:25894812-25910795 bp, - strand Genetic Position: Chr5, 12.35 cM, cytoband A3
• Alliance: Xrcc2^tm1Jtk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66529
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 3 (comprising 86% of the coding region) with a neomycin resistance cassette via homologous recombination. Absence of gene expression was confirmed by RT-PCR analysis of RNA isolated from homozygous mutant embryos. (J:66529)

Expression

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xrcc2 Mutation: 17 strains or lines available

Notes

ES cell line = MAC3

References

• Original: J:66529 Deans B, et al., Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice. EMBO J. 2000 Dec 15;19(24):6675-85
• All: 6 reference(s)