Egrm1^SM/J
QTL Variant Detail

Summary

• QTL variant: Egrm1^SM/J
• Name: early growth rate, maternal effect 1; SM/J
• MGI ID: MGI:2662785
• QTL: Egrm1 Location: Chr1:74991977-74992080 bp Genetic Position: Chr1, cM position of peak correlated region/allele: 38.55 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: Heterozygous animals exhibit increased growth rate compared to either LG/J homozygotes or SM/J homozygotes. (J:79520)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:79520

102 microsatellite markers were screened in a population of (LG/J x SM/J)F2 female animals to identify QTLs associated with early growth rate of pups from weeks 1-2. Early growth rate was used as a measure of maternal performance. Both direct effect QTLsand maternal effect QTLs were assessed. Two direct effect QTLs with genome-wide significance, Egrd1 and Egrd2, mapped to mouse Chromosomes 5 and 15, respectively. Egrd1 spans 88 cM - 118 cM on mouse Chromosome 5 with a peak LPR score at D5Mit26. Egrd2 spans 10 cM -54 cM on mouse Chromsome 15 with a peak LPR score at D15Mit5. Three maternal effect QTLs with genome-wide significance, Egrm1, Egrm2, and Egrm3, mapped to mouse Chromosomes 1, 6, and 7, respectively. Egrm1 spans 38 cM - 54 cM on mouse Chromosome1 witha peak LPR score at D1Mit7. Egrm2 spans 50 cM - 68 cM on mouse Chromosome 6 with a peak LPR score at D6Mit9. Egrm3 spans 44cM - 56 cM on mouse Chromosome 7 with a peak LPR score at D7Nds1.

References

• Original: J:79520 Wolf JB, et al., Contribution of maternal effect QTL to genetic architecture of early growth in mice. Heredity. 2002 Oct;89(4):300-10
• All: 1 reference(s)