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Egrm2SM/J
QTL Variant Detail
Summary
QTL variant: Egrm2SM/J
Name: early growth rate, maternal effect 2; SM/J
MGI ID: MGI:2662787
QTL: Egrm2  Location: Chr6:87402880-87403016 bp  Genetic Position: Chr6, cM position of peak correlated region/allele: 37.96 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  SM/J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
 
Mutation detailsHeterozygous animals exhibit increased growth rate compared to either LG/J homozygotes or SM/J homozygotes. (J:79520)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:79520

102 microsatellite markers were screened in a population of (LG/J x SM/J)F2 female animals to identify QTLs associated with early growth rate of pups from weeks 1-2. Early growth rate was used as a measure of maternal performance. Both direct effect QTLsand maternal effect QTLs were assessed. Two direct effect QTLs with genome-wide significance, Egrd1 and Egrd2, mapped to mouse Chromosomes 5 and 15, respectively. Egrd1 spans 88 cM - 118 cM on mouse Chromosome 5 with a peak LPR score at D5Mit26. Egrd2 spans 10 cM -54 cM on mouse Chromsome 15 with a peak LPR score at D15Mit5. Three maternal effect QTLs with genome-wide significance, Egrm1, Egrm2, and Egrm3, mapped to mouse Chromosomes 1, 6, and 7, respectively. Egrm1 spans 38 cM - 54 cM on mouse Chromosome1 witha peak LPR score at D1Mit7. Egrm2 spans 50 cM - 68 cM on mouse Chromosome 6 with a peak LPR score at D6Mit9. Egrm3 spans 44cM - 56 cM on mouse Chromosome 7 with a peak LPR score at D7Nds1.

References
Original:  J:79520 Wolf JB, et al., Contribution of maternal effect QTL to genetic architecture of early growth in mice. Heredity. 2002 Oct;89(4):300-10
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory