Cdh15^tm1Hha
Targeted Allele Detail

Summary

• Symbol: Cdh15^tm1Hha
• Name: cadherin 15; targeted mutation 1, Hans-Henning Arnold
• MGI ID: MGI:2663004
• Gene: Cdh15 Location: Chr8:123575113-123594136 bp, + strand Genetic Position: Chr8, 71.99 cM
• Alliance: Cdh15^tm1Hha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83398
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment encompassing the coding regions of exons 1 through 4 was replaced with a cassette containing nls-lacZ and PGK-neo. The deleted region encoded the signal peptide and extracellular domain 1, a putative mediator of homophilic binding. Transcript was undetected by Northern blot analysis of muscle tissue obtained from homozygous mutant mice. Western blot analysis of skeletal muscle and cerbellar tissue indicated an absence of protein. (J:83398)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh15 Mutation: 71 strains or lines available

References

• Original: J:83398 Hollnagel A, et al., The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration. Mol Cell Biol. 2002 Jul;22(13):4760-70
• All: 3 reference(s)