Parp2^tm1Jmdm
Targeted Allele Detail

Summary

• Symbol: Parp2^tm1Jmdm
• Name: poly (ADP-ribose) polymerase family, member 2; targeted mutation 1, Josiane Menissier de Murcia
• MGI ID: MGI:2663016
• Synonyms: parp-2^-
• Gene: Parp2 Location: Chr14:51045347-51058758 bp, + strand Genetic Position: Chr14, 26.25 cM, cytoband C1
• Alliance: Parp2^tm1Jmdm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83371
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by insertion of a PGK-hygromycin cassette into exon 9 (at isoleucine 285) via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of testis proteins using polyclonal antibodies against the catalytic domain or N-terminal domain. (J:83371)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Parp2 Mutation: 29 strains or lines available

References

• Original: J:83371 Menissier de Murcia J, et al., Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse. EMBO J. 2003 May 1;22(9):2255-63
• All: 22 reference(s)