Cldn5^tm1Sts
Targeted Allele Detail

Summary

• Symbol: Cldn5^tm1Sts
• Name: claudin 5; targeted mutation 1, Shoichiro Tsukita
• MGI ID: MGI:2663040
• Synonyms: Cld5^-
• Gene: Cldn5 Location: Chr16:18595597-18597012 bp, + strand Genetic Position: Chr16, 11.63 cM
• Alliance: Cldn5^tm1Sts page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83341
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire gene coding exon was replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant embryos was confirmed by RT-PCR analysis of brain mRNA. (J:83341)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cldn5 Mutation: 24 strains or lines available

References

• Original: J:83341 Nitta T, et al., Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol. 2003 May 12;161(3):653-60
• All: 4 reference(s)