Mndl1^SM/J
QTL Variant Detail

Summary

• QTL variant: Mndl1^SM/J
• Name: mandible length 1; SM/J
• MGI ID: MGI:2663058
• QTL: Mndl1 Location: unknown Genetic Position: Chr11, cM position of peak correlated region/allele: 14.44 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased mandible length compared to A/J. (J:78551)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:78551

400 polymorphic markers were screened in 21 SMXA (SM/J x A/J) recombinant inbred (RI) strains to identify QTLs associated with mandible size. Parental strain SM/J has a small mandible compared to parental strain A/J. Two significant QTLs, Mndl1 and Mndl2, mapped to 13 cM and 16 cM on mouse Chromosome 11, respectively. Mndl1 gives peak linkage between markers D11Mit152 and Hba with LOD>4.0. SM/J-derived alleles confer small mandible size at Mndl1 and a candidate gene mapping to the region is Otx1. Mndl2 gives peak linkage between markers D11Mit229 and D11Mit163 with LOD>4.0. A/J-derived alleles confer increased mandible size at Mndl2. A suggestive locus mapped to 60 cM on mouse Chromosome 10 with LOD>2.2 between D10Mit70 and D10Mit136. A/J-derived allelesare associated with small mandibles while SM/J-derived alleles are associated with large mandibles at this locus.

References

• Original: J:78551 Dohmoto A, et al., Quantitative trait loci on chromosomes 10 and 11 influencing mandible size of SMXA RI mouse strains. J Dent Res. 2002 Jul;81(7):501-4
• All: 1 reference(s)