Tg(Mpz-cre/ERT2)2Ueli
Transgene Detail

Summary

• Symbol: Tg(Mpz-cre/ERT2)2Ueli
• Name: transgene insertion 2, Ueli Suter
• MGI ID: MGI:2663097
• Synonyms: P0-CreER^T2, P0Cx-CreERT2, Tg(Mpz-cre/ESR1)2Ueli
• Transgene: Tg(Mpz-cre/ERT2)2Ueli Location: unknown
• Alliance: Tg(Mpz-cre/ERT2)2Ueli page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Mpz-cre/ERT2)2Ueli expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Mpz (24564)

  Mpz	(MGI:103177)

• Mutation details: 1.1 kb of rat Mpz promoter sequences control the expression of 350 bp from the 5' untranslated region of the human GJB1 gene and a cre-ESR1 cassette in Schwann cells. The GJB1 region includes exon 1, intron 1, and exon 2. The human ESR1 sequence is mutated at G400V, M543A, and L540A in the ligand-binding domain to allow activation by 4-hydroxytamoxifen (OHT) and ICI 182,780. (J:83361)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mpz (rat) Summary of all recombinase alleles driven by Mpz. Comparative matrix view of recombinase activities Alliance rat Mpz gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:83361 Leone DP, et al., Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells. Mol Cell Neurosci. 2003 Apr;22(4):430-40
• All: 11 reference(s)