Ccn2^tm1Kml
Targeted Allele Detail

Summary

• Symbol: Ccn2^tm1Kml
• Name: cellular communication network factor 2; targeted mutation 1, Karen M Lyons
• MGI ID: MGI:2663631
• Synonyms: Ccn2^-, Crgf-, CTGF^neo
• Gene: Ccn2 Location: Chr10:24471340-24474581 bp, + strand Genetic Position: Chr10, 11.84 cM, cytoband A3-B1
• Alliance: Ccn2^tm1Kml page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83260
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected in homozygous mutant mice by RT-PCR analysis. (J:83260)

Expression

In Mice Carrying this Mutation:	27 assay results
In Structures Affected by this Mutation:	28 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccn2 Mutation: 29 strains or lines available

References

• Original: J:83260 Ivkovic S, et al., Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development. 2003 Jun;130(12):2779-91
• All: 21 reference(s)