Rac1^tm1.1Djk
Targeted Allele Detail

Summary

• Symbol: Rac1^tm1.1Djk
• Name: Rac family small GTPase 1; targeted mutation 1.1, David J Kwiatkowski
• MGI ID: MGI:2663669
• Synonyms: Rac1^-, Rac1^tm1.1Glog
• Gene: Rac1 Location: Chr5:143491236-143513786 bp, - strand Genetic Position: Chr5, 82.22 cM
• Alliance: Rac1^tm1.1Djk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83457
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1 and a loxP site flanked neomycin resistance gene cassette into intron 1. The neo cassette was removed and exon 1 deleted through subsequent cre-mediated recombination, creating a null allele. (J:83457)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rac1 Mutation: 24 strains or lines available

References

• Original: J:83457 Glogauer M, et al., Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions. J Immunol. 2003 Jun 1;170(11):5652-7
• All: 20 reference(s)