Tbx4^tm1Pa
Targeted Allele Detail

Summary

• Symbol: Tbx4^tm1Pa
• Name: T-box 4; targeted mutation 1, Virginia Papaioannou
• MGI ID: MGI:2663714
• Synonyms: Tbx4^flox
• Gene: Tbx4 Location: Chr11:85777248-85806923 bp, + strand Genetic Position: Chr11, 51.42 cM
• Alliance: Tbx4^tm1Pa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83256
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 5, which encodes a portion of the T box, was flanked by a single loxP site in intron 4 and a floxed neo cassette in intron 5. (J:83256)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbx4 Mutation: 23 strains or lines available

Notes

Tbx4^tm1Pa and Tbx4^tm1.1Pa homozygotes exhibit essentially the same phenotype.

References

• Original: J:83256 Naiche LA, et al., Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantois. Development. 2003 Jun;130(12):2681-93
• All: 3 reference(s)