Tbx4^tm1.1Pa
Targeted Allele Detail

Summary

• Symbol: Tbx4^tm1.1Pa
• Name: T-box 4; targeted mutation 1.1, Virginia Papaioannou
• MGI ID: MGI:2663716
• Synonyms: Tbx4^null
• Gene: Tbx4 Location: Chr11:85777248-85806923 bp, + strand Genetic Position: Chr11, 51.42 cM
• Alliance: Tbx4^tm1.1Pa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83256
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Mating of Tbx4^tm1Pa mice and mice expressing cre recombinase in the germline resulted in the deletion of floxed region of Tbx4^tm1Pa, including exon 5 and the neo cassette. (J:83256)

Expression

In Mice Carrying this Mutation:	37 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tbx4 Mutation: 23 strains or lines available

Notes

Tbx4^tm1Pa and Tbx4^tm1.1Pa homozygotes exhibit essentially the same phenotype.

References

• Original: J:83256 Naiche LA, et al., Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantois. Development. 2003 Jun;130(12):2681-93
• All: 6 reference(s)