Agrn^tm4Jrs
Targeted Allele Detail

Summary

• Symbol: Agrn^tm4Jrs
• Name: agrin; targeted mutation 4, Joshua R Sanes
• MGI ID: MGI:2663725
• Synonyms: AGD^-, agrin^-, Agrn^Del, Agrn^tm1Klee
• Gene: Agrn Location: Chr4:156249747-156281945 bp, - strand Genetic Position: Chr4, 88.55 cM
• Alliance: Agrn^tm4Jrs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83827
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The endogenous locus was disrupted by the removal of a genomic fragment extending from within exon 6 into intron 33 (~9 kb). The deletion removed sequence encoding both the neural and non-neural isoforms. Protein was undetected in homozygous mutant mice by immunohistochemical and Western blot analyses. (J:83827)

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agrn Mutation: 102 strains or lines available

References

• Original: J:83827 Lin W, et al., Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse. Nature. 2001 Apr 26;410(6832):1057-64
• All: 17 reference(s)