Fpr1^tm1Gao
Targeted Allele Detail

Summary

• Symbol: Fpr1^tm1Gao
• Name: formyl peptide receptor 1; targeted mutation 1, Ji-Liang Gao
• MGI ID: MGI:2663726
• Synonyms: FPR^-, KO-FPR, mfpr1^-
• Gene: Fpr1 Location: Chr17:18096733-18104201 bp, - strand Genetic Position: Chr17, 10.63 cM
• Alliance: Fpr1^tm1Gao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53354
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 150 bp fragment, encoding the extracellular loop of the fourth transmembrane domain, was replaced with a neomycin selection cassette inserted by homologous recombination. Only truncated transcript was detected in homozygous mutant mice by RT-PCR analysis. (J:53354)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Fpr1 Mutation: 29 strains or lines available

References

• Original: J:53354 Gao JL, et al., Impaired antibacterial host defense in mice lacking the N-formylpeptide receptor. J Exp Med. 1999 Feb 15;189(4):657-62
• All: 33 reference(s)