Prkch^tm1Cda
Targeted Allele Detail

Summary

• Symbol: Prkch^tm1Cda
• Name: protein kinase C, eta; targeted mutation 1, Kazuhiro Chida
• MGI ID: MGI:2663731
• Synonyms: Prkch^-
• Gene: Prkch Location: Chr12:73631570-73824959 bp, + strand Genetic Position: Chr12, 30.81 cM, cytoband C3-D1
• Alliance: Prkch^tm1Cda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83498
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of the catalytic domain-containing exon 9 with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of epidermal proteins. (J:83498)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkch Mutation: 41 strains or lines available

References

• Original: J:83498 Chida K, et al., Disruption of protein kinase ceta results in impairment of wound healing and enhancement of tumor formation in mouse skin carcinogenesis. Cancer Res. 2003 May 15;63(10):2404-8
• All: 1 reference(s)