Slc5a3^tm1Gtb
Targeted Allele Detail

Summary

• Symbol: Slc5a3^tm1Gtb
• Name: solute carrier family 5 (inositol transporters), member 3; targeted mutation 1, Gerard T Berry
• MGI ID: MGI:2663787
• Synonyms: SMIT1^-/-
• Gene: Slc5a3 Location: Chr16:91855210-91884361 bp, + strand Genetic Position: Chr16, 53.44 cM
• Alliance: Slc5a3^tm1Gtb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83591
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire gene coding region was replaced with a PGK-neo cassette via homologous recombination. Northern blot analysis of fetal and placental mRNA confirmed the absence of gene expression in homozygous mutant animals. (J:83591)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc5a3 Mutation: 24 strains or lines available

References

• Original: J:83591 Berry GT, et al., Loss of murine Na+/myo-inositol cotransporter leads to brain myo-inositol depletion and central apnea. J Biol Chem. 2003 May 16;278(20):18297-302
• All: 9 reference(s)