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Socs3tm2Wsa
Targeted Allele Detail
Summary
Symbol: Socs3tm2Wsa
Name: suppressor of cytokine signaling 3; targeted mutation 2, Warren S Alexander
MGI ID: MGI:2663917
Synonyms: line 350, Socs3fl
Gene: Socs3  Location: Chr11:117856905-117860192 bp, - strand  Genetic Position: Chr11, 82.96 cM, cytoband E2
Alliance: Socs3tm2Wsa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83645
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    The entire gene was flanked with loxP sites and a PGK-neo cassette via homologous recombination. (J:83645)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Socs3 Mutation:  22 strains or lines available
References
Original:  J:83645 Croker BA, et al., SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol. 2003 Jun;4(6):540-5
All:  44 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory