Socs3^tm2.1Wsa
Targeted Allele Detail

Summary

• Symbol: Socs3^tm2.1Wsa
• Name: suppressor of cytokine signaling 3; targeted mutation 2.1, Warren S Alexander
• MGI ID: MGI:2663925
• Synonyms: Socs3^deltadel
• Gene: Socs3 Location: Chr11:117856905-117860192 bp, - strand Genetic Position: Chr11, 82.96 cM, cytoband E2
• Alliance: Socs3^tm2.1Wsa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83645
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is derived from Socs3^tm2Wsa by mating mutant animals to cre deleter strain TgN(CMV-cre)1Cgn, which results in excision of the entire gene coding region and the PGK-neo selectable marker. (J:83645)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Socs3 Mutation: 22 strains or lines available

References

• Original: J:83645 Croker BA, et al., SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol. 2003 Jun;4(6):540-5
• All: 2 reference(s)