Tg(Gfap-cre)2Brn
Transgene Detail

Summary

• Symbol: Tg(Gfap-cre)2Brn
• Name: transgene insertion 2, Anton Berns
• MGI ID: MGI:2663939
• Synonyms: GFAP-Cre, GFAP/Cre, mGFAP-Cre
• Transgene: Tg(Gfap-cre)2Brn Location: unknown
• Alliance: Tg(Gfap-cre)2Brn page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Gfap-cre)2Brn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gfap (MGI:95697)

• Mutation details: Transgene expressing bacteriophage P1 Cre recombinase under control of the mouse Gfap promoter. This transgene is expressed in the developing forebrain and in the spinal ganglia and also in scattered precursor cells located in the EGL of the cerebellum. (J:61961)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gfap (mouse) Summary of all recombinase alleles driven by Gfap. Comparative matrix view of recombinase activities Alliance mouse Gfap gene page

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
Loading...
cn1	Gt(ROSA)26Sor^tm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor^+ Rb1^tm2Brn/Rb1^tm2Brn Tg(Gfap-cre)2Brn/0	either: (involves: 129 * 129P2/OlaHsd * FVB/N) or (involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N)
cn2	Gt(ROSA)26Sor^tm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor^+ Rb1^tm2Brn/Rb1^tm2Brn Trp53^tm1Brn/Trp53^tm1Brn Tg(Gfap-cre)2Brn/0	either: (involves: 129 * 129P2/OlaHsd * FVB/N) or (involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N)
cn3	Gt(ROSA)26Sor^tm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor^+ Tg(Gfap-cre)2Brn/0	either: (involves: 129P2/OlaHsd * FVB/N) or (involves: 129P2/OlaHsd * C57BL/6 * FVB/N)
cn4	Rb1^tm2Brn/Rb1^tm2Brn Trp53^tm1Brn/Trp53^tm1Brn Tg(Gfap-cre)2Brn/0	involves: 129 * 129P2/OlaHsd * FVB/N
cn5  Disease Model	Rb1^tm2Brn/Rb1^tm2Brn Trp53^tm1Brd/Trp53^tm1Brd Tg(Gfap-cre)2Brn/0	involves: 129 * 129S7/SvEvBrd * FVB/N
cn6	Tnfrsf11a^tm1.1Pngr/Tnfrsf11a^tm1.2Pngr Tg(Gfap-cre)2Brn/0	involves: 129 * C57BL/6 * C57BL/6NTac * FVB/N
cn7	Rb1^tm2Brn/Rb1^tm2Brn Tg(Gfap-cre)2Brn/0	involves: 129 * FVB/N
cn8  Disease Model	Rb1^tm2Brn/Rb1^tm2Brn Trp53^tm1Brn/Trp53^tm1Brn Tg(Gfap-cre)2Brn/0	involves: 129P2/OlaHsd * FVB/N
cn9	Trp53^tm1Brn/Trp53^tm1Brn Tg(Gfap-cre)2Brn/0	involves: 129P2/OlaHsd * FVB/N
cn10	Slc6a9^tm1Veul/Slc6a9^tm1Veul Tg(Gfap-cre)2Brn/?	involves: 129P2/OlaHsd * FVB/N

Phenotypes:

Affected Systems	cn1	cn2	cn3	cn4	cn5	cn6	cn7	cn8	cn9	cn10
show or hide all annotated terms
behavior/neurological					√
tremors					√
ataxia					√
impaired balance					√
abnormal gait					√
circling					√
endocrine/exocrine glands	√	√	√	√			√
increased pituitary gland tumor incidence	√	√	√	√			√
increased mammary gland tumor incidence			√
homeostasis/metabolism						√
abnormal body temperature homeostasis						√
abnormal circadian temperature homeostasis						√
impaired febrile response						√
decreased prostaglandin level						√
abnormal response/metabolism to endogenous compounds						√
immune system						√
decreased susceptibility to endotoxin shock						√
integument			√
increased mammary gland tumor incidence			√
mortality/aging	√		√				√			√
premature death	√		√				√
postnatal lethality, incomplete penetrance										√
muscle										√
hypotonia										√
neoplasm	√	√	√	√	√		√	√
neoplasm	N						N
increased tumor incidence			√
increased pituitary gland tumor incidence	√	√	√	√			√
increased mammary gland tumor incidence			√
increased medulloblastoma incidence		√		√	√			√
increased carcinoma incidence		√		√			√
increased papilloma incidence				√
nervous system	√	√	√	√	√		√	√
increased pituitary gland tumor incidence	√	√	√	√			√
increased medulloblastoma incidence		√		√	√			√
normal phenotype									√
no abnormal phenotype detected									√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	cn5	cn8
medulloblastoma IDs medulloblastoma       DOID:0050902 DOID:0060105 DOID:168 DOID:3858 DOID:4981 MESH:D008527 MESH:D018242 NCI:C27294 NCI:C3222 NCI:C3716 OMIM:155255 ORDO:616 UMLS_CUI:C0025149 UMLS_CUI:C0206663 UMLS_CUI:C1334410 Close	√	√

Tumor Data

List all tumor models in MMHCdb carrying Tg(Gfap-cre)2Brn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:61961 Marino S, et al., Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev. 2000 Apr 15;14(8):994-1004
• All: 11 reference(s)