Bcl11a^tm1Ngc
Targeted Allele Detail

Summary

• Symbol: Bcl11a^tm1Ngc
• Name: BCL11 transcription factor A; targeted mutation 1, Neal G Copeland
• MGI ID: MGI:2663941
• Gene: Bcl11a Location: Chr11:24028056-24124123 bp, + strand Genetic Position: Chr11, 14.41 cM
• Alliance: Bcl11a^tm1Ngc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83646
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.4 kb region containing exon 1 was deleted and replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by Northern blot and immunohistochemical analysis of homozygous mutant brains. (J:83646)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bcl11a Mutation: 44 strains or lines available

References

• Original: J:83646 Liu P, et al., Bcl11a is essential for normal lymphoid development. Nat Immunol. 2003 Jun;4(6):525-32
• All: 6 reference(s)