Tg(NES-TVA)J12Ech
Transgene Detail

Summary

• Symbol: Tg(NES-TVA)J12Ech
• Name: transgene insertion J12, Eric C Holland
• MGI ID: MGI:2663944
• Synonyms: Nestin:Tva, Ntv-1, N-tva, Ntv-a, Tg(NES-TVA)12Hev
• Transgene: Tg(NES-TVA)J12Ech Location: unknown
• Alliance: Tg(NES-TVA)J12Ech page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene expresses TVA, the receptor for avian retrovirus ALV, subgroup A (ALV-A), from a quail cDNA under control of a modified human nestin promoter that includes the second-intron enhancer - which in adult mice directs expression specifically in early glial progenitor cells - and the herpes simplex virus thymidine kinase (HSV-TK) promoter. Cells presenting this receptor can be infected by replication-competent ALV splice acceptor (RCAS) vectors, permitting cell type specific expression of vector-borne genes. (J:52161)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(NES-TVA)J12Ech

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

Glial progenitor cells in transgenic mice are specifically susceptible to infection by viral vectors.

References

• Original: J:52161 Holland EC, et al., A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev. 1998 Dec 1;12(23):3675-85
• All: 94 reference(s)