Carm1^tm1Mtb
Targeted Allele Detail

Summary

• Symbol: Carm1^tm1Mtb
• Name: coactivator-associated arginine methyltransferase 1; targeted mutation 1, Mark T Bedford
• MGI ID: MGI:2663959
• Synonyms: Carm1^-
• Gene: Carm1 Location: Chr9:21458163-21500763 bp, + strand Genetic Position: Chr9, Syntenic
• Alliance: Carm1^tm1Mtb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83623
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutation: Insertion
• Mutation details: An FRT site flanked neomycin resisatnce gene cassette was inserted upstream of two exons encoding a portion of the cofactor binding domain (amino acids 117-187). Additionally, the inserted neo cassette and the two exons were flanked by a single loxP sites. Protein was undetected in homozygous mutant mice. (J:83623)

Expression

In Mice Carrying this Mutation:	46 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Carm1 Mutation: 94 strains or lines available

References

• Original: J:83623 Yadav N, et al., Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6464-8
• All: 11 reference(s)