Bcl11b^tm1Jpk
Targeted Allele Detail

Summary

• Symbol: Bcl11b^tm1Jpk
• Name: B cell leukemia/lymphoma 11B; targeted mutation 1, Japan Kominami
• MGI ID: MGI:2663971
• Synonyms: Bcl11b^-
• Gene: Bcl11b Location: Chr12:107876662-107969861 bp, - strand Genetic Position: Chr12, 59.1 cM, cytoband F1
• Alliance: Bcl11b^tm1Jpk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83651
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into exon 1 via homologous recombination. Absence of gene expression was confirmed by Western blot analysis of thymus proteins from homozygous mutant animals. (J:83651)

Expression

In Mice Carrying this Mutation:	186 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Bcl11b Mutation: 46 strains or lines available

References

• Original: J:83651 Wakabayashi Y, et al., Bcl11b is required for differentiation and survival of alphabeta T lymphocytes. Nat Immunol. 2003 Jun;4(6):533-9
• All: 22 reference(s)