Fkbp6^tm1Pngr
Targeted Allele Detail

Summary

• Symbol: Fkbp6^tm1Pngr
• Name: FK506 binding protein 6; targeted mutation 1, Josef M Penninger
• MGI ID: MGI:2663987
• Synonyms: Fkbp6^-
• Gene: Fkbp6 Location: Chr5:135320558-135378898 bp, - strand Genetic Position: Chr5, 75.11 cM
• Alliance: Fkbp6^tm1Pngr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83634
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Genomic sequence encompassing a portion of exon 6 and all of exon 7 was replaced with a neo cassette inserted by homologous recombination. Neither transcript nor protein were detected in testes of homozygous mutant mice by Northern or Western blot analyses. (J:83634)

Expression

In Mice Carrying this Mutation:	6 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fkbp6 Mutation: 13 strains or lines available

References

• Original: J:83634 Crackower MA, et al., Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis. Science. 2003 May 23;300(5623):1291-5
• All: 3 reference(s)