Fasn^tm1Schi
Targeted Allele Detail

Summary

• Symbol: Fasn^tm1Schi
• Name: fatty acid synthase; targeted mutation 1, Subrahmanyam S Chirala
• MGI ID: MGI:2664027
• Synonyms: Fasn-, Fasn^tm1sc
• Gene: Fasn Location: Chr11:120696672-120715373 bp, - strand Genetic Position: Chr11, 84.56 cM
• Alliance: Fasn^tm1Schi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83624
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment encompassing exons 11 through 18 was replaced with an hprt cassette inserted by homologous recombination. The deleted region encoded the acetyl and malonyl-transacylases and dehydratase domains. (J:83624)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fasn Mutation: 89 strains or lines available

References

• Original: J:83624 Chirala SS, et al., Fatty acid synthesis is essential in embryonic development: Fatty acid synthase null mutants and most of the heterozygotes die in utero. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6358-63
• All: 1 reference(s)