Mbd1^tm1Fhg
Targeted Allele Detail

Summary

• Symbol: Mbd1^tm1Fhg
• Name: methyl-CpG binding domain protein 1; targeted mutation 1, Fred H Gage
• MGI ID: MGI:2664084
• Synonyms: MBD1^-, Mbd1KO
• Gene: Mbd1 Location: Chr18:74400676-74415803 bp, + strand Genetic Position: Chr18, 50.7 cM
• Alliance: Mbd1^tm1Fhg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83613
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 10 were replaced by homologous recombination of a targeting vector containing lacZ and neo. The deleted region encoded the MBD1, CXXC1, CXXC2, and CXXC3 domains. Transcript was undetected in homozygous mutant brain tissue by Northern blot analysis and in situ hybridization. (J:83613)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mbd1 Mutation: 33 strains or lines available

References

• Original: J:83613 Zhao X, et al., Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6777-82
• All: 8 reference(s)