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Vent1C57BL/6J
QTL Variant Detail
Summary
QTL variant: Vent1C57BL/6J
Name: ventricular size 1; C57BL/6J
MGI ID: MGI:2664103
QTL: Vent1  Location: Chr8:31831686-34743564 bp  Genetic Position: Chr8, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased cerebral ventricular size compared to DBA/2J. (J:83649)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:83649

228 animals from 26 AXB and BXA recombinant inbred (RI) strains were analyzed at 669 genetic loci to identify QTLs linked to cerebral ventricular size. Parental strain A/J exhibits a small ventricle compared to parental strain C57BL/6J.

A QTL named Vent1 mapped to an interval spanning 13 cM - 18 cM on mouse Chromosome 8. Vent1 reaches a peak LOD score of 4.1 between D8Mit94 and D8Mit189. C57BL/6J-derived alleles confer increased ventricular size at Vent1.

A highly significant (LRS=45.1) interaction was detected between D4Mit237 (13.3 cM) on mouse Chromosome 4 and D7Mit178 (0.5 cM) on mouse Chromosome 7. These loci were named Vent2 and Vent3, respectively. C57BL/6J-derived alleles at both Vent2 and Vent3 confers increased ventricle size. A possible candidate gene for Vent2 is Tgfbr1.

References
Original:  J:83649 Zygourakis CC, et al., Quantitative trait loci modulate ventricular size in the mouse brain. J Comp Neurol. 2003 Jun 30;461(3):362-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory