Summary |
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Variant origin |
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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Expression |
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:83649228 animals from 26 AXB and BXA recombinant inbred (RI) strains were analyzed at 669 genetic loci to identify QTLs linked to cerebral ventricular size. Parental strain A/J exhibits a small ventricle compared to parental strain C57BL/6J. A QTL named Vent1 mapped to an interval spanning 13 cM - 18 cM on mouse Chromosome 8. Vent1 reaches a peak LOD score of 4.1 between D8Mit94 and D8Mit189. C57BL/6J-derived alleles confer increased ventricular size at Vent1.A highly significant (LRS=45.1) interaction was detected between D4Mit237 (13.3 cM) on mouse Chromosome 4 and D7Mit178 (0.5 cM) on mouse Chromosome 7. These loci were named Vent2 and Vent3, respectively. C57BL/6J-derived alleles at both Vent2 and Vent3 confers increased ventricle size. A possible candidate gene for Vent2 is Tgfbr1. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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