Psl2^C57BL/6
QTL Variant Detail

Summary

• QTL variant: Psl2^C57BL/6
• Name: promotion susceptibility QTL 2; C57BL/6
• MGI ID: MGI:2664123
• QTL: Psl2 Location: unknown Genetic Position: Chr2, cM position of peak correlated region/allele: 76.74 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to skin tumors compared to DBA/2.
• Inheritance: Recessive

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:83608

310 female (C57BL/6 x BXD-27/Ty)F2 animals were analyzed for QTLs associated with sensitivity to TPA-induced skin tumors. Parental strain C57BL/6 is resistant to TPA-induced skin tumors whereas parental strain BXD-27/Ty is susceptible. The strongest linkage was detected at 87 cM on mouse Chromosome 2 near D2Mit286 and was named Psl2 (promotion susceptibility QTL 2). DBA/2-derived alleles confer dominant susceptibility to TPA-induced tumors at this locus. A locus with an additive effect, Psl3 mapped to 111 cM on mouse Chromosome 1 near D1Mit511. C57BL/6-derived alleles confer susceptibility to TPA-induced tumors at this locus. Lastly, Psl4 mapped to 47 cM on mouse Chromosome 19 near D19Mit38. C57BL/6-derived alleles confer dominant resistance to TPA-induced tumors at Psl4.

References

• Original: J:83608 Angel JM, et al., Identification of Novel Genetic Loci Contributing to 12-O-Tetradecanoylphorbol-13-acetate Skin Tumor Promotion Susceptibility in DBA/2 and C57BL/6 Mice. Cancer Res. 2003 Jun 1;63(11):2747-51
• All: 1 reference(s)