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Arrd3C57BL/6J
QTL Variant Detail
Summary
QTL variant: Arrd3C57BL/6J
Name: age-related retinal degeneration 3; C57BL/6J
MGI ID: MGI:2664157
QTL: Arrd3  Location: Chr16:32522909-65466552 bp  Genetic Position: Chr16, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers susceptibility to age-related retinal degeneration compared to BALB/cByJ.
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:83546

86 markers at an average resolution of 15.7 cM were screened in 268 (BALB/cByJ x C57BL/6J-Tyrc-2J)F2 animals to identify QTLs associated with age-related retinal degeneration. Parental strain BALB/cByJ exhibits greater retinal photoreceptor loss at 8 months of age compared to parental strain C57BL/6J-Tyrc-2J.

A significant locus for age-related retinal degeneration, Arrd1, mapped to an interval spanning 32.5 cM - 37.5 cM on mouse Chromosome 6 with a peak LOD score of 13.5 between D6Mit209 and D6Mit284. C57BL/6J-derived alleles confer dominant resistance to retinal degeneration at Arrd1.

Arrd2 mapped to an interval spanning 11 cM - 21 cM on mouse Chromosome 10 with a peak LOD score of 6.4 between D10Mit213 and D10Mit126. C57BL/6J-derived alleles confer additively inherited resistance to retinal degeneration at Arrd2.

Arrd3 mapped to a broad interval spanning 23.4 cM - 55.2 cM on mouse Chromosome 16 with a peak LOD score of 7.1 between D16Mit60 and D16Mit139. BALB/cByJ-derived alleles confer dominant resistance to retinal degeneration at Arrd3.

Suggestive QTLs mapped to 5 cM on mouse Chromosome 14 with LOD=2.7 at D14Mit126, 38 cM on mouse Chromosome 18 with LOD=2.6 at D18Mit208, 16 cM on mouse Chromosome 12 with LOD=2.6 at D12Mit60, 24 cM on mouse Chromosome 13 with LOD=2.5 at D13Mit19, and 53 cM on mouse Chromosome 8 with LOD=2.1 at D8Mit47. C57BL/6J-derived alleles confer resistance to retinal degeneration at all loci except D12Mit60 where BALB/cByJ-derived alleles confer resistance.

References
Original:  J:83546 Danciger M, et al., A strong and highly significant QTL on chromosome 6 that protects the mouse from age-related retinal degeneration. Invest Ophthalmol Vis Sci. 2003 Jun;44(6):2442-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory