Hbb^tm1Tow
Targeted Allele Detail

Summary

• Symbol: Hbb^tm1Tow
• Name: hemoglobin beta chain complex; targeted mutation 1, Timothy Townes
• MGI ID: MGI:2664239
• Synonyms: Hbb⁰, Hbb^th3, Hbb^tm1Tmt
• Gene: Hbb Location: unknown Genetic Position: Chr7, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29087
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Hbb^tm1Tow involves 2 genes/genome features (Hbb-b1, Hbb-b2) View all
• Mutation details: A genomic fragment encompassing all of Hbb-b1 and a 5' portion of Hbb-b2 was replaced with a neo cassette inserted by homologous recombination. (J:29087)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hbb Mutation: 47 strains or lines available

References

• Original: J:29087 Ciavatta DJ, et al., Mouse model of human beta zero thalassemia: targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells. Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9259-63
• All: 113 reference(s)